Sistema citocromo p450 pdf

Algumas drogas podem inibir enzimas p450 e esta inibicao pode levar a interacoes potenciais com outros farmacos. Citocromo p450 uma protena integral da membrana mitocondrial interna. Citocromo p450 3a4 cyp3a4 citocromo p450 3a4 speaker. A metabolizacao no sistema do citocromo p450 e a sua importancia. A maioria dos frmacos sofre biotransformao, frequentemente envolvendo a oxidao no fgado. P450 oxidoreductase, p450 reductase, por, cpr, cypor is a membranebound enzyme required for electron transfer from nadph to cytochrome p450 and other heme proteins including heme oxygenase in the endoplasmic reticulum of the. Aspectos fundamentales del citocromo p450 fundacion tejerina. Devlin 2002, santiago et al 2002,finn 2009,robotton 2003. Sistema citocromo p450 1871 palavras trabalhosfeitos. All structured data from the file and property namespaces is available under the creative commons cc0 license. Understanding the cyp system is essential for advanced practitioners aps, as the consequences of drugdrug interactions can be profound. Cytochrome p450 enzymes are involved in the phase i of xenobiotic metabolism.

The cytochrome p450dependent monooxygenases constitute the primary enzyme system responsible for the oxidative metabolism of a variety of xenobiotics and endogenous compounds including drugs, carcinogens, fatty acids and hormones. P450 oxidoreductase, p450 reductase, por, cpr, cypor is a membranebound enzyme required for electron transfer from nadph to cytochrome p450 and other heme proteins including heme oxygenase in the endoplasmic reticulum of the eukaryotic cell. Nadphadrenodoxina redutase e adrenodoxina so protenas perifricas, no mergulhadas na membrana. Ingelmansundberg m, sim sc, gomez a, rodriguezantona c 2007. Pdf citocromo p450 y sus subfamilias citocromo p450. O citocromo p450 liga ao oxigenio, quando o reductase. Actividad del citocromo p450 y su alteracion en diversas patologias. Influence of cytochrome p450 polymorphisms on drug therapies.

The monooxygenase system consists of multiple forms of p450 enzymes, nadphcytochrome reductase and phospholipids. Files are available under licenses specified on their description page. Powerpoint slides english spanish translation common. Cytochrome p450 cyp is a hemeprotein that plays a key role in the metabolism of drugs and other xenobiotics estabrook, 2003. Pdf the organisms are constantly exposed to a wide array of xenobiotics.

The human genome project has identified 57 human genes coding for the various cytochrome p450 enzymes. Cytochrome p450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver. The cytochrome p450 dependent monooxygenases constitute the primary enzyme system responsible for the oxidative metabolism of a variety of xenobiotics and endogenous compounds including drugs, carcinogens, fatty acids and hormones. Denominase interao drogadroga aos efeitos indesejados causados pela induo ou inibio dos citocromos p450. Download as pptx, pdf, txt or read online from scribd.